Allosteric Site
Non-Covalent GPX4 Inhibitors
Uncover cryptic allosteric sites
Background
• Glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis, playing an essential role in various cellular processes.
• The flat surface of GPX4 poses a significant challenge for drug design due to the lack of well-defined binding pockets.
• Most GPX4 inhibitors with cellular activity depend on covalent binding to selenocysteine-46, which often leads to poor selectivity and high toxicity.
Approach
Results
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